The No. 8 Oklahoma Sooners (8-2) face a fellow SEC opponent when they host the No. 23 Missouri Tigers (7-3) on Saturday, November 22, 2025 at Gaylord Family Oklahoma Memorial Stadium.
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Oklahoma vs. Missouri Matchup Info
- Game date: Saturday, November 22, 2025
- Game time: 12 p.m. ET
- Location: Norman, Oklahoma
- Venue: Gaylord Family Oklahoma Memorial Stadium
- TV channel: ABC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Oklahoma vs. Missouri Odds and Prediction
- Spread favorite: Sooners (-6.5)
- Moneyline: Sooners (-265), Tigers (+214)
- Total: 42 points
- Pick ATS: Oklahoma (-6.5)
- Pick OU: Over (42)
- Prediction: Oklahoma 30, Missouri 18
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Oklahoma vs. Missouri Betting Records and Insights
- Oklahoma has covered six times in 10 games with a spread this season.
- Missouri has won six games against the spread this season, failing to cover four times.
- The Sooners have covered the spread twice this season (2-2 ATS) when playing as at least 6.5-point favorites.
- The Tigers have been an underdog by 6.5 points or more this season once, and failed to cover the spread.
- Oklahoma games have hit the over just twice this season.
- So far this year, six of Missouri's 10 games with a set number have gone over the point total.