When the Kansas City Chiefs play the New York Giants at 8:20 p.m. ET on Sunday, Sept. 21, our projection system predicts the Chiefs will win the game. Our model also projects the spead, point total, and final score, which you can read below.
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Chiefs vs. Giants Game Info and TV Channel
- When: Sunday, September 21, 2025 at 8:20 p.m. ET
- Where: MetLife Stadium in East Rutherford, New Jersey
- TV: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Chiefs vs. Giants Odds and Betting Info
- Spread favorite: Chiefs (-6)
- Moneyline: Chiefs (-308), Giants (+246)
- Total: 44.5 points
Chiefs vs. Giants Prediction
- Pick ATS: Chiefs (-6)
- Pick OU: Under (44.5)
Prediction:
Chiefs 28 - Giants 12
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Chiefs vs. Giants Betting Insights
- The Chiefs are winless against the spread this season (0-2-0).
- The Giants have a record of 1-1-0 against the spread this year.
- New York has been an underdog by 6 points or more this season once, and failed to cover the spread.
- Chiefs games have gone over the point total once this season.
- Giants games have hit the over once this season.
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